2021-01-13 · DNC is a cold blood cardioplegia modified with a higher level of potassium. It was initially developed by Professor Pedro Del Nido at the University of Pittsburgh given the use in children's immature myocardium [ 3 ].
Del Nido cardioplegia was initially used in pediatric patients and has been expanding into adult cardiac centers over the last decade. It can be used as a single dose and it is a reasonable tool do decrease cardioplegic interventions. 2021-01-13 A novel formula for inducing cardioplegia was introduced in congenital heart surgery in 1995.5,6 Led by Pedro del Nido, MD, researchers from the University of Pittsburgh patented this formula as a single dose of a modified depolarizing solution. Commonly referred to as ‘‘del Nido … The del Nido cardioplegia is a crystalloid solution (Plasma-Lyte A, lidocaine, magnesium sulfate, potassium chloride, mannitol, sodium bicarbonate), mixed with blood in a 1:4 ratio (blood/crystalloid). Lidocaine is believed to be the primary component, as it increases the myocyte refractory period and reduces sodium and calcium influx.
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Conclusions: It is safe to use del Nido cardioplegia in coronary artery bypass grafting combined with heart valve replacement in adults, which can reduce the frequency of cardioplegia infusion and simplify the surgical procedure. The trend of troponin concentration suggests that del Nido cardioplegia has a better myocardial protective effect. Del Nido (DN) cardioplegia solution provides a depolarized hyperkalemic arrest lasting up to 60 minutes, and the addition of lidocaine may limit intracellular calcium influx. A novel formula for inducing cardioplegia was introduced in congenital heart surgery in 1995.5,6 Led by Pedro del Nido, MD, researchers from the University of Pittsburgh patented this formula as a single dose of a modified depolarizing solution. Commonly referred to as ‘‘del Nido solution,’’ this blood and crystalloid Del Nido cardioplegia was initially used in pediatric patients and has been expanding into adult cardiac centers over the last decade.
del Nido cardioplegia (DC) offers prolonged cardiac protection with single-dose administration and has been shown to be safe in adult CABG surgery. We set out to evaluate the efficacy of cardiac protection and clinical outcomes of DC versus standard blood cardioplegia (BC) in minimally invasive aortic valve surgery.
del Nido versus St. Thomas Cardioplegia Solutions: A Single-Center Retrospective Analysis of Post Cross-Clamp Defibrillation Rates. Buel ST , Striker CW , O'Brien JE J Extra Corpor Technol , 48(2):67-70, 01 Jun 2016
This study compared the effects of DNC versus traditional blood-based cardioplegia on postoperative complications in patients who underwent coronary artery bypass grafting (CABG). Cardioplegia is an important strategy for myocardial protection during cardiac surgery. This meta-analysis was to compare the effects of del Nido and conventional cardioplegia in adult patients.
The del Nido solution is a cardioplegia solution that has been applied to adult patients owing to its advantage in achieving a relatively long duration of cardiac arrest with a single dose. However, the del Nido solution is not available in Japan, and there is no report of del Nido solution use in Japan.
The del Nido cardioplegia solution was essentially developed for use in paediatric cardiac surgery as myocardial protection in the immature heart was considered to be different than in the adult heart [ 2, 3 ]. It was subsequently tried in adult cardiac surgery, with good results. Cardioplegia solutions have been used for myocardial protection in cardiac surgery for decades. Different cardioplegic strategies have been evaluated.
Following the cross-clamp period, the heart returned to normal sinus rhythm without need for defibrillation. Composition of del Nido and Blood Cardioplegia Solutions. Del Nido solution is composed of mixed blood and Plasma-Lyte A (1:4) (total volume: 1060 mL). Mannitol (3.26 g), potassium chloride (K, 26 mEq), magnesium sulphate (Mg, 2 g), lidocaine (130 mg), and sodium bicarbonate (13 mEq) were added to the del Nido solution. del Nido cardioplegia solution was developed in the early 1990s by Dr Pedro del Nido and colleagues at the University of Pittsburg . It is an extracellular cardioplegia solution, with the major vehicle being Plasmalyte-A, which is a balanced salt solution with a composition similar to plasma.
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It was primarily designed for children and it has been used in pediatric cardiac surgery in Boston's Children Hospital since 1994. There are few studies regarding the del Nido cardioplegia. OBJECTIVES: Del Nido cardioplegia is a non-glucose-based solution given as a single dose that provides up to 180 minutes of cardiac quiescence.
DOI: 10.21470/1678-9741-2020-0063
Some cardioplegias, such as del Nido or Histidine-Tryptophan-Ketoglutamate solutions, offer an advantage over blood and other crystalloid cardioplegia as they only require one administration during short cardiac surgeries, compared to multiple hits required by blood and other crystalloid.
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Del Nido cardioplegia: from an infant conceive to an adult life - a brief review of the current evidence in adult patients Vessel Plus is an open acccess journal, which publishes articles related to vascular diseases, including acute respiratory distress syndrome, aneurysm, atherosclerosis, hypertension, stroke, peripheral vascular or pulmonary vascular diseases, etc.
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The convenience offered by a single-dose cardioplegia strategy is the avoidance of interruption of the flow of surgery and, more importantly, a significant reduction in the cross-clamp time. del Ni
Objectives: Del Nido cardioplegia (DNC) has been shown to be safe in adults with normal coronary arteries who are undergoing valve surgery. This study compared the effects of DNC versus traditional blood-based cardioplegia on postoperative complications in patients who underwent coronary artery bypass grafting (CABG). Cardioplegia is an important strategy for myocardial protection during cardiac surgery. This meta-analysis was to compare the effects of del Nido and conventional cardioplegia in adult patients. From November 2016 to October 2017, Del Nido cardioplegia was used in 131 consecutive patients (DN group) and compared using a propensity score to 251 patients who had received intermittent cold blood cardioplegia (CB group) and operated during the immediate period prior. All patients were operated by one surgeon (FJ).